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Guide for
Cold Sores Treatment Online

By Medical Editor: 
Dr. Francesco-Maria Serino, MD, PhD

September, 2024

Summary

Cold sores are small, painful blisters primarily caused by the herpes simplex virus type 1 (HSV-1). They often appear around the lips and mouth, triggered by factors like stress, illness, or sun exposure. These sores progress through stages, from tingling and blistering to oozing and crusting, and are most contagious when open and oozing. Antiviral medications such as valacyclovir (Valtrex) and acyclovir can speed up healing, while over-the-counter creams and natural remedies like lysine or tea tree oil may provide additional relief. Recurring outbreaks can be managed with daily suppressive antiviral therapy. To reduce transmission, avoid close contact, such as kissing, especially during active outbreaks.

What are Cold Sores?

Cold sores, also known as fever blisters, are small, painful blisters that appear around the lips, mouth, or even inside the mouth. They are caused primarily by the herpes simplex virus (HSV), with herpes simplex virus type 1 (HSV-1) as the main culprit. These sores can also appear on other parts of the face, and occasionally in the eye, leading to a condition called herpes simplex keratitis.

While less common, herpes simplex virus type 2 (HSV-2), typically associated with genital herpes, can sometimes cause cold sores through oral contact. Cold sores often begin as tiny bumps on the lips or mouth, eventually forming blisters. They are usually triggered by factors like stress, illness, sun exposure, or fatigue, and can be mistaken for other types of lip irritation.

What Causes Cold Sores?

Cold sores are caused by an infection with the herpes simplex virus, which can remain dormant in nerve cells and reactivate during periods of stress or immune suppression. Common triggers include:

  • Physical or emotional stress
  • Fatigue or sleep deprivation
  • Exposure to strong sunlight or UV rays
  • Illnesses, like colds or fevers
  • Hormonal changes

Individuals with HSV-1 may experience recurrent cold sore outbreaks. Where cold sores appear—whether on the lips, tongue, or inside the mouth—depends on the site of infection and any triggers that cause the virus to reactivate. While pets like dogs cannot get cold sores, humans can spread the virus to others through direct contact.

Are Cold Sores Always Herpes?

Yes, cold sores are almost always caused by the herpes simplex virus, typically HSV-1. Some people wonder if cold sores mean they have an STD, but HSV-1 is mainly spread through nonsexual contact, such as kissing or sharing items like utensils or lip balm. In rare cases, HSV-2, usually associated with genital herpes, can cause cold sores through oral-genital contact.

Other conditions, like allergic reactions or certain skin conditions, may cause lip or mouth bumps that resemble cold sores but are not due to herpes. If you’re unsure, a medical provider can confirm a diagnosis through a physical examination or a specific test for HSV.

Are Cold Sores Contagious?

Yes, cold sores are highly contagious. The virus can be spread through close personal contact, such as kissing or sharing items like utensils and towels, especially when an active sore is present. People are most contagious when the sore is open and oozing, but cold sores can still spread even when they appear to be healing or are in the form of tiny bumps on the lip.

Cold sores are also contagious in the early stages, when a person may feel tingling or itching around the lips, and for about 7-10 days until they are fully healed. Some may wonder, “Are all cold sores herpes?”—the answer is yes, in most cases, cold sores are caused by the herpes simplex virus.

Cold Sores Symptoms

Cold sore symptoms typically progress through stages:

  • Tingling or itching: A tingling sensation or slight itching often occurs before the sore appears.
  • Blisters: Small, fluid-filled blisters form, usually around the lips or mouth area.
  • Oozing and crusting: The blisters may break open, releasing fluid and forming a crust. This stage is highly contagious.

Cold sores typically last 7-10 days. While the sores are healing, some people experience mild pain or discomfort. You may wonder, “Do cold sores hurt?”—yes, they can, especially during the blistering and oozing stages. Cold compresses or cool, damp cloths can help ease discomfort.

Cold Sores Treatment

Treating cold sores can help reduce symptoms and speed up healing time. Here are some common treatments:

  • Antiviral medications: Prescription antivirals like valacyclovir (Valtrex) and acyclovir are commonly used. Standard valacyclovir dosage for cold sores is often 1 gram taken twice daily for a day, but your doctor may adjust it based on your needs.
  • Over-the-counter (OTC) options: Creams with ingredients like docosanol or benzyl alcohol can help shorten the outbreak duration. Lysine supplements are also popular as a natural remedy, and some find relief with tea tree oil or aloe vera.
  • Home remedies: Applying a cool compress, using a lip balm with zinc, or avoiding spicy foods can also reduce discomfort. Ice may also help by numbing the area.

For those with frequent outbreaks, daily suppressive therapy with a low dose of antiviral medication can help prevent future episodes. Why do I keep getting cold sores? Frequent recurrence may be due to underlying triggers like stress, lack of sleep, or immune system fluctuations.


While cold sores are common, effective treatment and preventive strategies can help manage outbreaks and reduce discomfort.

Did you know that...

HSV-1 can spread in surprising ways, beyond the typical skin-to-skin contact. For example, athletes, especially wrestlers, sometimes develop herpes gladiatorum. This happens when the virus enters through tiny skin abrasions caused by close physical contact, leading to outbreaks on areas like the face, neck, and arms. It’s unique because, instead of needing mucosal surfaces like the mouth, HSV-1 spreads through these small skin cuts, making close-contact sports an unexpected route for transmission.

Common cold sores medications

Icon of a prescription cream

Acyclovir

topical cream

Icon of a pill bottle

Valacyclovir

oral tablets

How can Doctorsa Virtual Care help with an Herpes flare up?

No matter where you are, our platform quickly connects you with doctors for immediate virtual care, available 24/7. A doctor can assess your symptoms and discuss online treatment options to help with your cold sores symptoms. You can even receive prescriptions right in your email, along with follow-up care, all from the comfort of wherever you happen to be. It’s the ideal solution for international travelers looking for fast and reliable medical support.

References

Korr, G., Thamm, M., Czogiel, I., et al. (2017). Decreasing seroprevalence of herpes simplex virus type 1 and type 2 in Germany leaves many people susceptible to genital infection: time to raise awareness and enhance control. BMC Infectious Diseases, 17, 471.

McQuillan, G., Kruszon-Moran, D., Flagg, E. W., & Paulose-Ram, R. (2018). Prevalence of herpes simplex virus type 1 and type 2 in persons aged 14-49: United States, 2015-2016. NCHS Data Brief.

Malvy, D., Halioua, B., Lançon, F., et al. (2005). Epidemiology of genital herpes simplex virus infections in a community-based sample in France: Results of the HERPIMAX study. Sexually Transmitted Diseases, 32, 499.

Horowitz, R., Aierstuck, S., Williams, E. A., & Melby, B. (2010). Herpes simplex virus infection in a university health population: Clinical manifestations, epidemiology, and implications. Journal of American College Health, 59, 69.

Anderson, B. J., McGuire, D. P., Reed, M., et al. (2016). Prophylactic valacyclovir to prevent outbreaks of primary herpes gladiatorum at a 28-day wrestling camp: A 10-year review. Clinical Journal of Sport Medicine, 26, 272.

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How does it work?

99% of our users solve their issue within 1 hour. No waiting, no language barriers, no insurance needed.

Answer a few questions

Just answer a few questions about your cold sores outbreak and choose a convenient time for your online session. It’s simple and hassle-free, with no need to sign up.

Select and connect

Doctors respond in minutes. Select your preferred one and start your virtual consultation right from your web browser.

7-day free follow-up chat

Reach out to your doctor with any questions you might have, at no extra cost for 7 days following your consultation.

A tourist in Europe taking a picture of a picturesque street, mobile phone shows Doctorsa intake questionnaire, a medication pill bottle

How does it work?

99% of our users solve their issue within 1 hour. No waiting, no language barriers, no insurance needed.

Answer a few questions

Just answer a few questions about your cold sores symptoms and choose a convenient time for your online session. It’s simple and hassle-free, with no need to sign up.

Select and connect

Doctors respond in minutes. Select your preferred one and start your virtual consultation right from your web browser.

7-day free follow-up chat

Reach out to your doctor with any questions you might have, at no extra cost for 7 days following your consultation.

Your questions answered

Prescription antiviral medications like valacyclovir (Valtrex) or acyclovir can speed up healing if taken at the first signs of a cold sore, such as tingling or itching. Over-the-counter creams with docosanol may also help reduce symptoms. Home remedies, like applying a cold compress, can offer quick relief but won’t kill the virus.

Cold sores usually last 7-10 days from the first tingling to complete healing. They typically follow a cycle: tingling, blistering, oozing, and finally crusting over as they heal.

Cold sores can be triggered by stress, illness (like a cold or fever), hormonal changes, sun exposure, or even fatigue. These triggers activate the dormant herpes simplex virus, causing an outbreak.

Cold sores are most contagious from the start of tingling until the sore is fully healed, typically 7-10 days. They can spread through direct contact even before blisters are visible and remain contagious until crusted over.

Open the intake form and choose one of the following options:

  • Urgent Care: For immediate treatment of your cold sores via virtual care.
  • Set Up an Appointment: To schedule a same-day or future appointment.
  • Prescription Refill: Use this option if you have lost or forgotten your medication.

Next, select how you would like to receive appointment offers from doctors.
We recommend using WhatsApp as it is faster and more reliable. You will quickly receive various visit options. Choose the one that suits you best and proceed to online payment.

Video visits are browser-based, so no apps are needed. Simply click the link you receive to start your video visit in your browser.

After the consultation, expect to receive an invoice and an e-prescription via email. You can show or print the e-prescription to purchase medication at the pharmacy of your choice.

Following the consultation, the doctor will either email the e-prescription to you or send it via WhatsApp. You can then either print it out or show it directly to the pharmacist when purchasing the medication.

It’s important to understand that doctors must responsibly evaluate each case individually. They can’t simply prescribe medication solely based on a patient’s request or a recommendation from another doctor without confirming that it’s suitable for the patient’s specific condition.

The total cost may differ based on the providers. Each one competes for your request, offering a fair price tailored to your needs. On average, an online doctor visit costs 25 Euros. Prices for in-person appointments, specialists, and lab work vary by city. You can send a request to learn more—there’s no commitment to book, and you can select your provider.

Please note that the visit fee doesn’t cover medication expenses, but common antibiotics are quite affordable in Europe. The cost of antibiotic treatment typically ranges from 5 to 15 euros approximately.

Yes, whenever you submit your request it is instantly received by the doctors active at that time. Whether it’s late at night, on a Sunday morning, or on New Year’s Eve, there’s always someone on the other side who’s ready to see you. When you receive an option for an appointment, there’s a person behind it (a doctor) who’s read your request and is willing to assist you.

You can message your physician with follow-up questions at no additional cost for up to 7 days after the video visit.

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